Aberrant glycosylation occurs in the majority of human cancers and changes in mucin-type O-glycosylation are key events that play a role in the induction of invasion and metastases. These changes generate novel cancer-specific glyco-antigens that can interact with cells of the immune system through carbohydrate binding lectins. These glycans can be carried on many mucin-type glycoproteins including MUC1.
This is an open access article distributed under the terms of Creative Commons Attribution License. Although progress in the early detection, diagnosis and treatment of breast cancer has been achieved in recent decades, the disease remains a significant global health burden 34. Accurate biomarkers for early diagnosis and more accurate prognosis could improve the efficiency of current treatments for breast cancer and represent molecular markers for targeted therapy 5.
A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation. Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern.
Mouse over the terms for more detail; many indicate links which you can click for dedicated pages about the topic. Data table showing topics related to specific cancers and associated disorders. Scope includes mutations and abnormal protein expression.
Antibody-derived chimeric antigen receptor CAR T cell therapy has achieved gratifying breakthrough in hematologic malignancies but has shown limited success in solid tumor immunotherapy. MUC28z was well-expressed on the surface of engineered activated human T cells. There are limited treatment options for patients with TNBC.
P Q7Z Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs. MUC1 is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein.
Study record managers: refer to the Data Element Definitions if submitting registration or results information. Vaccines made from peptides may help the body build an effective immune response to kill tumor cells. Giving booster vaccinations may make a stronger immune response and prevent or delay the recurrence of cancer.
Impact factor 8. Nanotheranostics - Submit manuscript now International Journal of Biological Sciences.
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